Prince M. – TechConnect Briefs

An investigation into methodologies for the modification of contact angle for MX crystallography

Burton C., Prince M., Topham P., Docker D. Axford P., Orville G. Evans A., Kay J., Stuart D., Aston University, UK

This paper describes a detailed investigation into a range of surface modifications for manipulating the hydrophobicity of X-ray compatible materials for the application of surface microfluidics. With traditional microfluidics, as the scale of a fluid [...]

The Development of an Automated Nano Sampling Handling System for Nanometre Protein Crystallography Experiments

Docker P., Axford D., Prince M., Cordovez B., Kay J., Stuart D., Evans G., Diamond light Source, UK

As the world’s synchrotrons and X-FELs endeavour to meet the need to analyse ever-smaller protein crystals, there grows a requirement for a new technique to present nano-dimensional samples to the beam for X-ray diffraction experiments.The [...]

The application of 3D printing to study microfluidic architecture for ‘on chip’ mixing systems for SRCD and UV spectroscopy

Prince M., Docker P., Burton C., Hussain R., Kay J., Silgardi G., Diamond light Source, UK

Circular dichroism (CD) is the differential absorption of left- and right-handed circularly polarized light. It is a form of spectroscopy used to determine the optical isomerism and secondary structure of molecules, and to study a [...]

The Automation of Protein Crystal Presentation for X Ray Diffraction Experiments using Standing Acoustic Waves in a Microfluidic Chip Environment

Burton C., Docker P., Prince M., Leaper M., Kay J., Stuart D., Evans G., Diamond light Source, UK

As the pressure continues to grow on Diamond and the world’s synchrotrons for higher throughput of diffraction experiments, new and novel techniques are required for presenting these micron dimension crystals to the X ray beam. [...]