Pai C.L. – TechConnect Briefs

AS1411 aptamer-conjugated polymeric micelle for targetable cancer therapy

Lai P.S., Pai C.L., Hsu C.Y., National Chung Hsing University, TW

Targetable drug delivery system is a promising tool for cancer treatments. Herein we report a novel strategy of using G-quadruplex AS1411 aptamer-conjugated polyethylene-polylactide formed polymeric micelles (apt-PEG-PLA-PM) as a drug carrier to target cancer cells [...]

Studies on the Subcellular Trafficking of PAMAM Dendrimer

Lai P.S., Shieh M.J., Pai C.L., Wang C.Y., Lou P.J., National Taiwan University, TW

Polyamidoamine (PAMAM) dendrimers are a new class of highly branched spherical polymers and have emerged as a novel synthetic drug and gene carrier. However, the fate of the dendrimer-nucleotide complexes in a biological environment and [...]