Ma K-S – TechConnect Briefs

Fabrication of Nanometer-Sized Structures by C-NEMS Technology

Ma K-S, Madou M., Jia G-Y, Xu Q., Zhou H., Wang C-L, Zoval J., Madou M., University of California Irvine, US

We have demonstrated a technique to fabricate carbon nano wires of controllable dimension and location using a top-down methodology. The width and thickness of the wires are in the tens of nanometer range. Additionally, the [...]

Fast DNA Immobilization and Hybridization on a CD (Compact Disc) Microfluidic Platform

Jia G., Ma K-S, Madou M.J., Kido H., Zoval J.V., Madou M.J., University of California at Irvine, US

A CD-based flow-through approach for DNA immobilization on gold surfaces was proposed and validated using 25-mer thiol-derivatized nucleotides (T-SH) labeled with fluorescent (Cy3) dye. Amino-derivatized ssDNA (T-amino) of the same sequence was used as a [...]

Electrical Detection of DNA Hybridization using Adjacent Impedance Probing (AIP) Method

Zhou H., Ma K-S, Madou M., Zoval J., Madou M., University of California Irvine, US

Sensitivity and selectivity are two of the most challenging criteria for the development of DNA biosensor devices. These biosensor devices have attracted interest for the rapid identification of pathogens in humans, animals, and plants, for [...]

Detection of DNA Hybridyzation with Impedance Amplifying Labels

Ma K-S, Madou M., Zhou H., Fischetti A., Zoval J., Madou M., University of California Irvine, US

Traditionally used nucleic acid analysis detection platforms rely on fluorescent or radioactive labels. Optical techniques require large and expensive equipment such as automated colorimetric and fluorimetric instruments that greatly increase the cost of the whole [...]