Lopez T. – TechConnect Briefs

Cu/TiO2-SiO2 Nanostructured Materials for Brain Cancer Treatment

Ortiz-Islas E., Guevara P., Gómez E., Monroy H., Novaro O., National Institute of Neurology and Neurosurgery, MX

In the present work, we are reporting the toxic effect to brain cancer cells exerted by copper complexes loaded (CC) on a binary oxide. For this purpose, the TiO2-SiO2 oxide was prepared using the sol-gel [...]

Copper complexes loaded on nanostructured TiO2 materials as citotoxic agents of cancer cells

Lopez T., Guevara P., Gómez E., Instituto Nacional de Neurologia y Neurocirugia, MX

In the present work ammonium tetrachlorocuprate (II) and copper (II) chloride were loaded on nanostructured mesoporous titania for determinate their anticancer properties. Copper-TiO2 materials were prepared using the sol-gel technology. Characterization of Copper complexes and [...]

Molar variation of water: alkoxy in the preparation of SiO2-DA materials and its effect on dopamine release from an implantable reservoir in the brain

Lopez T., Esquivel D., Garcia E., National Institute of Neurology and Neurosurgery, MX

In the present work we report the dopamine (DA) molecules stabilization in the network of nanostructured silica materials with the objective of using these as reservoirs of DA release in the brain. For this purpose [...]

Nanosized titania reservoirs for epilepsy treatment

Kozina A., Espinoza K.A., Ortiz-Islas E., Rivero I.A., Lopez T., Instituto Nacional de Neurologia y Neurocirugia ‘MVS’, MX

Around 50 million people in the world suffer from epilepsy. Although there is no cure for this disease, with the right type and dosage of anti-epileptic medication the majority of patients can have their seizures [...]

The Effect of Water on Particle Size, porosity, and the Rate of Drug Release from Implanted Titania Resrvoirsia

Lopez T., Hernandez-Ayala A., Odriozola J.A., Quintana P., Gonzalez R.D., Lottici P.P., Marino I., Tulane University, US

In this study, sol-gel titania implants used in the controlled rate of drug release of valproic acid to the temporal lobe of the brain were optimized to insure that the correct drug dose is delivered. [...]

Spectroscopical and Structural Studies of Sol-gel Reservoirs used as Implants in the Delivery of Dopamine to the Central Nervous System

Lopez T., Esquivel D., Ascencio J., Odriozola J.A., Gonzalez R.D., Tulane University, US

The stabilization of dopamine used in the treatment of Parkinsons is a pressing problem. When dopamine is applied systemically. destabilization may occur following penetration through the blood brain barrier (BBB). In order to circumvent this [...]