Lai P.S. – TechConnect Briefs

Mn-Zn Ferrite and Photosensitizer Co-Loaded Cancer Theranostic Agent for Magnetic Resonance Imaging and Photodynamic Therapy

Lai P.S., Lai S.M., Yang M.-D., Tung M.-J., Lai P.S., Lai S.M., National Chung Hsing University, TW

Developing a nanodevice with simultaneous cancer imaging and therapy is one of the promising approaches for cancer treatments. In this report, a multifunctional cancer theranostic system based on magnetic resonance (MR) contrast agent and photosensitizer [...]

Clusters of Iron Oxide Nanoparticles for Efficient Magnetic Resonance Imaging

Lai P.S., Lai S.M., Lai P.S., Lai S.M., National Chung Hsing University, TW

Recently, self-assembling clusters of metal nanoparticles have been extensively investigated in various fields. To prepare these clusters, various ionic surfactants, have been employed as stabilizers or emulsifiers to form water-dispersed spherical clusters. However, these ionic [...]

Photocurable Composite with Antimicrobial Activity for Wound-Healing

Chang M-H, Ding F.-C., Ju W.-Y., Lai P.S., National Chung Hsing University, TW

To develop an appropriate approach that can accelerate the wound healing rate or prevent other microorganisms contamination is necessary for wound healing. In this study, the combination of antimicrobial activity and photodynamic antimicrobial chemotherapy of [...]

Overcome the Doxorubicin Resistance by Multimodal Nanoparticles in Mice

Lai P.S., Hsu C.Y., Lu H.-L., Yu H.-P., Syu W.-J., Shieh M.J., National Chung Hsing University, TW

The efficacy of many chemotherapeutic agents is reduced in cells that have developed multiple drug resistance (MDR). To address this important problem, a biodegradable polymer was coupled to the photosensitizer and the resulting photosensitizer-nanoparticles were [...]

Vitamin E-assisted Superparamagnetic Iron Oxide Clusters Formation for Magnetic Resonance Imaging

Lai J-R, Lai P.S., Yen H-C, Hsu C.Y., Lai J-R, Lai P.S., National Chung Hsing University, TW

Magnetic Resonance Imaging (MRI) has been regard as a noninvasive powerful imaging tool that yields excellent soft-tissue contrast, has a high spatial resolution, and possesses tomographic capabilities. Among the contrast agents used for MRI, superparamagnetic [...]

Bioluminescent quantum dots induced photodynamic therapy in vitro

Hsu C.Y., Lai P.S., Rao J.H., National Chung Hsing University, TW

Photodynamic therapy (PDT) is an innovative method for cancer treatment which involves the administration of a photosensitizing agent followed by exposure to the visible light. Appreciate light source to induce photosensitizing agent is the key [...]

AS1411 aptamer-conjugated polymeric micelle for targetable cancer therapy

Lai P.S., Pai C.L., Hsu C.Y., National Chung Hsing University, TW

Targetable drug delivery system is a promising tool for cancer treatments. Herein we report a novel strategy of using G-quadruplex AS1411 aptamer-conjugated polyethylene-polylactide formed polymeric micelles (apt-PEG-PLA-PM) as a drug carrier to target cancer cells [...]

Microwave-assisted superparamagnetic FePt synthesis for MRI application

Tsai J.L., Tsai M.J., Tsai T.Y., Tsai J.L., Tsai M.J., Tsai T.Y., Tsai J.L., Tsai M.J., Tsai T.Y., Lai P.S., National Chung Hsing University, TW

uperparamagnetic iron oxide (SPIO) nanoparticles have demonstrated their practicability as MRI T2-shortening agents for non-invasive cell labeling, drug delivery or tumor detections in clinical practice. Recently, superparamagnetic chemically disordered face-centered cubic (fcc) FePt nanoparticles has [...]

Synthesis and Photodynamic Efficacy of PAMAM-Photosensitiser Conjugates in Vitro

Peng C.L., Lai P.S., Lai T.-Y., Chiu C.H., Chang C-C, Lai P.S., Lai T.-Y., Shieh M.J., National Taiwan University, TW

Starburst polyamidoamine (PAMAM) dendrimer is a new class of highly branched spherical polymer. Covalent attachment of porphyrin to PAMAM dendrimer may alter the pharmacokinetics, cell targeting, and photophysical properties of photosensitizer. We investigated the uptake, [...]

Shell Cross-Linked Nanoparticle Based on Poly(e-caprolactone)-Poly(ethylene glycol) for Photosensitizer Delivery

Lai P.S., Huang M.Y., Wang S.J.J., Chen C.N., Shieh M.J., National Taiwan University, TW

Photodynamic therapy (PDT) is a novel photochemical process for producing localized tissue necrosis, which involves the activation of a photosensitizing drug in the target tissue with light of a specific wavelength matched to an absorption [...]