Jaiswal A.R. – TechConnect Briefs

Schwann Cells and Dorsal Root Ganglion Neurons Are Differentially Susceptible to Oxidative Stress Induced by Silicon Dioxide Nanoparticles

Lai J.C.K., Jaiswal A.R., Idikuda V.K., Pfau J., Bhushan A., Leung S.W., Idaho State University College of Pharmacy, US

Silicon dioxide (SiO2) particles, including nanoparticles, have been increasing employed in diverse industrial and biomedical applications including those in drug formulations, food, and cosmetics as SiO2 has been generally regarded as a non-toxic substance. However, [...]

Cytotoxicity of Magnesium Oxide Nanoparticles in Schwann Cells

Idikuda V.K., Jaiswal A.R., Wong Y.Y.W., Bhushan A., Leung S.W., Lai J.C.K., Idaho State University, US

Diverse applications of metal oxide nanoparticles in various industries have been accelerating in the last decade. Magnesium oxide (MgO) nanoparticles have been employed in ceramics, and as adhesive and additive in chemical raw materials, leading [...]

Molecular Effects of Silicon Dioxide Nanoparticles on Cell Survival Signaling of Dorsal Root Ganglion (DRG) Neurons and Schwann Cells

Jain A., Jaiswal A.R., Lu S., Wong Y.Y.W., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University, US

The molecular mechanisms underlying the pathophysiology of peripheral neuropathies have not been fully elucidated. To meet the need for suitable cell culture models in vitro of peripheral nervous system (PNS) neural cells that allow long-term [...]

Effects of Silicon Dioxide Nanoparticles on Peripheral Nervous System Neural Cell Models

Jaiswal A.R., Lu S., Pfau J., Wong Y.Y.W., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University, US

Cell model systems in vitro facilitate the high through-put screening of putative toxicity of a variety of nanomaterials, including nanoparticles. However, most of such cell models consisted of non-neural cells. We have developed several central [...]

Differential Cytotoxic Effects of Titanium Oxide Nanoparticles on Peripheral Nervous System Neural Cells

Lu S., Jaiswal A.R., Wong Y.Y.W., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University College of Pharmacy, US

The health impact of exposure to TiO2 nanoparticles is poorly documented although exposure to the particles is known to elicit inflammatory responses in lung tissue. We recently found treatment with TiO2 micro- or nanoparticles induce [...]