Hsu C.Y. – TechConnect Briefs

Overcome the Doxorubicin Resistance by Multimodal Nanoparticles in Mice

Lai P.S., Hsu C.Y., Lu H.-L., Yu H.-P., Syu W.-J., Shieh M.J., National Chung Hsing University, TW

The efficacy of many chemotherapeutic agents is reduced in cells that have developed multiple drug resistance (MDR). To address this important problem, a biodegradable polymer was coupled to the photosensitizer and the resulting photosensitizer-nanoparticles were [...]

siRNA and Paclitaxel Loaded PEG-PCL-PEI Tri-block Polymeric Micelle for Gene and Chemo-therapy Applications in Multidrug-resistance cancer cell

Hsu C.Y., National Chung Hsing University, TW

An annoying problem of chemotherapy was the drug resistance of cancer cell which was expression of multidrug-resistance associated proteins and resulted in ineffective treatment. To conquer this problem, a small interfering RNA (siRNA) molecule and [...]

Vitamin E-assisted Superparamagnetic Iron Oxide Clusters Formation for Magnetic Resonance Imaging

Lai J-R, Lai P.S., Yen H-C, Hsu C.Y., Lai J-R, Lai P.S., National Chung Hsing University, TW

Magnetic Resonance Imaging (MRI) has been regard as a noninvasive powerful imaging tool that yields excellent soft-tissue contrast, has a high spatial resolution, and possesses tomographic capabilities. Among the contrast agents used for MRI, superparamagnetic [...]

Bioluminescent quantum dots induced photodynamic therapy in vitro

Hsu C.Y., Lai P.S., Rao J.H., National Chung Hsing University, TW

Photodynamic therapy (PDT) is an innovative method for cancer treatment which involves the administration of a photosensitizing agent followed by exposure to the visible light. Appreciate light source to induce photosensitizing agent is the key [...]

AS1411 aptamer-conjugated polymeric micelle for targetable cancer therapy

Lai P.S., Pai C.L., Hsu C.Y., National Chung Hsing University, TW

Targetable drug delivery system is a promising tool for cancer treatments. Herein we report a novel strategy of using G-quadruplex AS1411 aptamer-conjugated polyethylene-polylactide formed polymeric micelles (apt-PEG-PLA-PM) as a drug carrier to target cancer cells [...]