Holmes B. – TechConnect Briefs

3D Printed Venous Valves, Biocompatibility and Functionality

Holmes B., Nanochon LLC, George Washington University, US

3D printing has been gaining popularity as a method of creating heart valves. However, to the best of our knowledge, no one was yet able to 3D print venous valves, particularly using cells or biocompatible [...]

Testing of a 3D printed, nanostructured osteochondral implant for knee repair in a small animal model

Holmes B., Kuo C-Y, Arumugasaamy N., Gandhi N., Rossi C., Fisher J.P., Zhang L., Oetgen M., Nanochon, Children's National Medical Center, US

Osteochondral lesions of the knee are difficult injuries to treat [1, 2]. Despite improvements in the diagnosis of these lesions, optimal treatment remains elusive, likely as a result of the complex interactions between host factors [...]

Functionality and degradation of 3D-printed polymeric scaffolds for mandibular reconstruction and vascularized bone tissue repair

Bulusu K.V., Holmes B., Paulson P., Zhang L.G., Plesniak M.W., The George Washington University, US

One of the greatest challenges in field of maxillofacial and craniofacial reconstruction is to quickly and adequately induce a vascular network within any large sections of repaired bone tissue. In this study we are addressing [...]

A synergistic approach to the design, fabrication and evaluation of 3D printed micro and nano featured scaffolds for vascularized bone tissue repair

Holmes B., Bulusu K., Plesniak M., Zhang L.G., Nanochon LLC, George Washington University, US

In recent years, 3D printing has become a popular and widely investigated method for the fabrication of large bone implants. 3D printed bone constructs, devices and treatments hold great potential to repair traumatic and chronic [...]

Enhanced Mechanical and Cytocompatibility Properties of Novel 3D Printed Osteochondral Scaffolds

Holmes B., Zhang LG., The George Washington University, US

A series of novel 3D osteochondral computer aided models were designed including a homogenous cross-hatched structure, a bi-phasic structure consisting of a cross hatched pattern and an intersecting rings structure, and a biphasic “key” model [...]

MWCNTs and SWCNTs based Nanocomposites for Cartilage and Bone Tissue Regeneration

Zhang L.G., Holmes B., The George Washington University, US

Cartilage and bone defects, which are caused by a variety of reasons such as traumatic injuries, osteoarthritis, osteoporosis or bone cancers, represent common and severe clinical problems. Developments in nanotechnology and tissue engineering have provided [...]