Hieke A. – TechConnect Briefs

Influence of metallic, ceramic, and plastic MALDI surface materials on the ionization efficiency and quality of mass spectrometric data

Hieke A., Stanford University, School of Medicine, US

Imperfections of the MALDI ionization process of proteins and peptides impose considerable limitations on the utility of mass spectrometry in basic life sciences and ultimately on the application in biomarker discovery and medical diagnostics. Improved [...]

Monte Carlo simulations of 1keV to 100keV electron trajectories from vacuum through solids into air and resulting current density and energy profiles

Hieke A., GEMIO Technologies, Inc., US

Increased awareness to use environmentally friendly methods for surface sterilization has rejuvenated interest in methods based on electron beam irradiation. Thus far, Monte Carlo electron beam simulations have been described either as typical electron optics [...]

Ion Sources for Biomolecules with Controlled Superposition of Electric and Pneumatic Fields

Hieke A., Ciphergen Biosystems, Inc., US

As previously reported the design of advanced ion sources for collisionaly cooled biomolecules required the development of an advanced multi-physics simulation system GEMIOS (Gas and Electromagnetic Ion Optical Simulator). Recent research based on such GEMIOS [...]

Development of an Advanced Simulation System for the Analysis of Particle Dynamics in LASER based Protein Ion Sources

Hieke A., Ciphergen Biosystems, Inc., US

An advanced multi-physics simulation system henceforth referred to as GEMIOS (Gas and Electromagnetic Ion Optical Simulator) has been implemented which allows the computation of 3D trajectories and energy exchange of ion beams/clouds under the influence [...]

Large Scale FDTD Simulation for Microoptics and Metamaterial Investigations – Current Possibilities and Verification Benchmarks

Hieke A., Tramel R., CFD Research Corporation, US

The study of microsystems containing photonic crystals (PC) and meta-materials are rapidly growing fields of research. Finite-Difference Time-Domain (FDTD) full wave electromagnetic solvers are now increasingly used to investigate and design such systems. However, in [...]

Designing Efficient Computer Experiments for Metamodel Generation

Crary S.B., Woodcock D.M., Hieke A., Crary Group, US

We demonstrate the relative merits of IZ-optimal designs for computer experiments relative to Latin hypercube designs, using two examples, both in two factors and eleven points, one a simple function from Welch et al. [1] [...]

Influence of Element Size on the Precision and Required Computational Effort for 3D FEM Interconnect Capacitance Simulations of ULSI DRAM Cells

Hieke A., Infineon Technologies Corporation, US

A fundamental proble of all FEM capacitance computations in MEMS and ULSI is to determine proper mesh size for the elements representing the considered model. In particular, opticaml mesh size selection is crucial for large [...]

Simple ADPL Implementation of a 3D FEM Simulator for Mutual Capacitances of Arbitrarily Shaped Objects Like Interconnects

Hieke A., Siemens Microelectronics, US

This paper describes the implementation of an ANSYS Parametric Design Language (APDF) macro called CACACO for the computation of capacitance matrixes of arbitrarily shaped 3D objects in arbitrarily distributed dielectrics via the conservation of field [...]