Heller M.J. – TechConnect Briefs

DNA Double-Write Photolithography: A Synergy for Top-Down and Bottom-Up Nanofabrication

Heller M.J., Song Y., University of California San Diego, US

Intrinsic programmability and other unique properties of DNA allow it to be used as a self-assembly nanostructure material, easily functionalized with nanoparticles and other entities, and as a UV sensitive write material for patterning. Thus, [...]

Dielectrophoretic Isolation and Detection of Cancer Related DNA and RNA Nanoparticulate Biomarkers from Blood and Plasma

Heller M.J., Marciniak J., Skowronski E., Sonnenberg A., University of California San Diego, US

The analysis of cell free circulating (cfc) DNA and RNA nanoparticulate biomarkers continues to become more widely used for cancer diagnostics and management. Generally, cfc-DNA for “liquid biopsies” is isolated form plasma using relatively long [...]

Isolation and Detection of Cancer Related DNA Nanoparticulate Biomarkers Directly from CLL Patient Blood “Rapid Sample to Sequence Diagnostics”

Heller M.J., Marciniak J., Sonnenberg A., University of California San Diego, US

The analysis of cell free circulating (cfc) DNA biomarkers continues to become more widely used for cancer diagnostics and management. Cfc-DNA ranges from nucleosomes and high molecular weight DNA nanoparticulates to 100-200bp fragments. We have [...]

Design and Fabrication of a Large Scale Electric Field Array Device for Directed Self-Assembly of Multilayer BioDerivatized Nanoparticle Materials

Heller M.J., Song Y., University of California San Diego, US

In earlier work, an electronic microarray device was used to carry out a bottom-up approach for the directed self-assembly of higher order 3D structures from biotin/streptavidin, DNA and enzyme derivatized nanoparticles. Structures with up to [...]

Peptide Nanoparticle Catalysis

Heller M.J., Cheung M., Takahashi T., University of California San Diego, US

Improved catalysis for more efficient chemical processing, biomass conversions and water oxidation-hydrogen production will be important for achieving new clean technologies. Our research work involves a novel approach to produce catalytic mechanistic properties in synthetic [...]

New High Conductance DEP Devices for Detection of Cancer Related DNA Nanoparticulate Biomarkers and Nanoparticles in Whole Blood

Heller M.J., Sonnenberg A., University of California San Diego, US

The ability to rapidly detect cell free circulating (cfc) DNA nanoparticulate biomarkers, drug delivery nanoparticles and virus directly from blood is a major challenge for nanomedicine. We have now developed unique, simple and practical high [...]

Detection of Cancer Related DNA Nanoparticulate Biomarkers and Nanoparticles in Whole Blood

Heller M.J., Krishnan R., Sonnenberg A., University of California San Diego, US

The ability to rapidly detect DNA nanoparticulate biomarkers and drug delivery nanoparticles directly in blood is a major challenge for early disease detection and nanomedicine. We now show that a microarray dielectrophoretic (DEP) device can [...]

Multilayer BioDerivatized Nanoparticle Composites by Electric Field Directed Self-Assembly

Heller M.J., Haiso A.P., University of California San Diego, US

An electronic microarray has been used to carry out directed self-assembly of higher order 3D structures from biotin/streptavidin, DNA and enzyme derivatized nanoparticles. Structures with up to fifty layers of alternating biotin and streptavidin, DNA [...]

Electric Field Process for the Fabrication of Higher Order Structures form Biomolecule Derivatized Nanoparticles

Heller M.J., Dehlinger D., Sullivan B., Esener S., University of California San Diego, US

An electronic microarray has been used to carry out directed self-assembly of higher order 3D structures from Biotin/Streptavidin and DNA derivatized nanoparticles. Structures with up to fifty layers of alternating biotin and streptavidin and DNA [...]

Electrophoretically Actuated Nanoscale Optoentropic Transduction Mechanisms

Sullivan B., Dehlinger D., Zlatanovic S., Esener S., Heller M.J., University of California San Diego, US

We have identified a novel oscillatory optoentropic transduction mechanism that may enable modern communications theory to augment DNA and protein target detection within complex biological samples. More specifically, we have shown that electric field driven [...]