Griffiths D. – TechConnect Briefs

Thorough Characterization of Liposomes by Complementary Light and X-Ray Scattering Techniques

Ragheb R., Bolze J., Taylor G., Tamaddoni N., Griffiths D., Nobbmann U., Malvern Panalytical, US

Liposomes are spherical vesicles with an aqueous core enclosed by one or more phospholipid bilayers or lamellae and are frequently classified based on their size and number of bilayers [1]. They are often used in [...]

Rapid High Resolution Multi-Parameter Characterization of Liposome-Protein Complexes by Nanoparticle Tracking Analysis

Ragheb R., Esposito E., Griffiths D., Malvern Instruments, US

Aggregation of biological and synthetic materials is a source of tremendous concern, posing problems at various stages of discovery and formulation processes. The ability to identify and characterize aggregates is of broad utility, and experiments [...]

Multi-Parameter Characterization of Nanoparticle Dispersions by Size, Count and Scattering Intensity

Griffiths D., Bernt W., Hole P., NanoSight USA, US

Nanoparticle Tracking Analysis (NTA) is a method that has gained increasing popularity for the study of nanoparticle dispersions, providing high-resolution particle size analysis as well as a direct measure of particle count or concentration. By [...]

Single Particle Resolution Zeta Potential Technique

Griffiths D., Bernt W., Hole P., Sullivan J., Malloy A., Carr B., NanoSight USA, US

A novel addition to a technique for the analysis of nanoparticles in a suspension is described. The Nanoparticle Tracking Analysis (NTA) technique visualizes then sizes individual nanoparticles, based on their Brownian motion. Unlike classical light [...]

Counting and Sizing of Virus and Protein Aggregates by Nanoparticle Tracking Analysis (NTA)

Griffiths D., Hole P., Smith J., Malloy A., Carr B., NanoSight, US

A new analytical system is described which provides total particle count and high-resolution size measurements for biological structures such as virus and protein aggregates. This system builds on the Nanoparticle Tracking and Analysis (NTA) technique [...]

Size and Count of Nanoparticles by Scattering and Fluorescence Nanoparticle Tracking Analysis (NTA)

Griffiths D., Hole P., Smith J., Malloy A., Carr B., NanoSight, US

A novel addition to a technique for the analysis of nanoparticles in a suspension is described. The Nanoparticle Tracking Analysis (NTA) technique sizes individual nanoparticles, based on their Brownian motion. Unlike classical light scattering techniques, [...]

Characterisation of Nanoparticle Dispersions by Size and Scattering Intensity Simultaneously

Griffiths D., Hole P., Smith J., Carr B., NanoSight USA West, US

A novel extension to the Nanoparticle Tracking and Analysis (NTA) technique is described. Previously a nanoparticle dispersion’s size distribution could be measured by simultaneously tracking many particles and directly (unlike DLS/SLS) calculating the particle size [...]