Establishing a GMP manufacturing site for nanoparticles
Sepulveda C.A., Roth J.A., Lu C., Ji L., Ramesh R., O’Connor S., Sadeghi T., Flagge F., Baez O., Shen A.C., Mondesir E., Jenkins J., Shpall E., McMannis J.D., University Texas MD Anderson Cancer Center, US
An active clinical trial at MD Anderson Cancer Center uses DOTAP:Chol liposomes as a non-viral vector for gene therapy. This therapeutic product needs to be produced fresh for each administration. Originally, the manufacture of the [...]