Dukhande V.V. – TechConnect Briefs

New in Vitro Strategy of Astrocytoma (Astrocytes-like) Cells Treated with Pioglitazone ( PPAR gamma agoinst) Offers Neuroprotection Against Nanoparticle-Induced Cytotoxity

Wong Y.Y.W., Jaiswal A., Dukhande V.V., Bhushan A., Leung S.W., Lai J.C.K., Idaho State University, US

Recently, we and others have developed several cell models for the investigation of the molecular mechanisms underlying the cytotoxicity of nanoparticles of several metallic and non-metallic oxides. These important findings have raised the awareness for [...]

Elucidation of Neuroprotective Properties of Astrocytoma (Astrocytes-like) Cells in Neural Cell Culture Models In Vitro: Applications in Tissue Engineering and Nanotoxicology

Wong Y.Y.W., Jaiswal A., Dukhande V.V., Bhushan A., Leung S.W., Lai J.C.K., Idaho State University, US

Evidence is accumulating that cell culture models in vitro facilitate high throughput and mechanistic studies in tissue engineering. We have developed several cell models for the systematic investigation of molecular mechanisms underlying the putative cytotoxicity [...]

Chitosan Film/Membrane as a Surface to Alter Brain Glioma Growth and Migration

Gao W.J., Wang Y.-H., Gu H.-Y., Jandhyam S., Dukhande V.V., Lai J.C.K., Lai M.B., Leung S.W., Bhushan A., Lai J.C.K., Lai M.B., Idaho State University, US

A hydrophilic polysaccharide derived from chitin, chitosan has gained increasing popularity in biomedical applications such as tissue engineering, wound dressing, and drug delivery because of its presumed biocompatibility. These applications were founded on chemical similarities [...]

Cytotoxicity of metallic oxide nanoparticles in human neural and non-neural cells

Lai J.C.K., Lai M.B., Jandhyam S., Dukhande V.V., Bhushan A., Daniels C.K., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University College of Pharmacy & Biomedical Research Institute, US

The use of nanomaterials in industrial applications (e.g., drug delivery, additives to drugs and cosmetics) has escalated in the last decade, leading to the possibility of their becoming environmental pollutants. However, these cytotoxic and other [...]

A Non-Contact Culture Model for Investigating Cell Signaling and Nanotoxicity

Gao W.J., Dukhande V.V., Jandhyam S., Wang Y.-H., Gu H.-Y., Lai J.C.K., Lai M.B., Lai J.C.K., Lai M.B., Leung S.W., Idaho State University, US

There is general agreement that in vitro cell model systems offer many advantages over in vivo model systems in elucidation of cell signaling and other mechanisms underlying a toxicant’s effect. While the 3-D cell models [...]

A Co-Culture Model for Nanotoxicity and Tissue Engineering Studies

Wang Y.-H., Jandhyam S., Dukhande V.V., Gao W.J., Gu H.-Y., Lai J.C.K., Lai M.B., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University College of Pharmacy & Biomedical Research Institute, US

Cell model systems in vitro play vital roles in recent advances in toxicological and tissue engineering research. They are particularly versatile in facilitating signaling and related mechanistic studies. Although the 3-D cell models better simulate [...]

Differential Cytotoxicity of Metallic Oxide Nanoparticles in Mammalian Cells

Lai J.C.K., Lai M.B., Jandhyam S., Dukhande V.V., Bhushan A., Daniels C.K., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University, US

Nanomaterials have been increasingly used in industrial applications (e.g., drug delivery, additives to drugs and cosmetics). Because of their wide use, occupational exposure to nanomaterials and nanoparticles may pose as health risks. Recent studies have [...]

Silicon Dioxide Nanoparticles Exert Dissimilar Cytotoxic Effects on Mammalian Cell Types

Jandhyam S., Lai J.C.K., Lai M.B., Dukhande V.V., Bhushan A., Daniels C.K., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University, US

Applications of nanomaterials (e.g., silicon dioxide (SiO2) nanoparticles) are ubiquitous. Thus, environmental and occupational exposure to these nanoparticles could pose potential health risk. SiO2 microparticles are toxic in animals in vivo and SiO2 nanoparticles are [...]