Daniels C.K. – TechConnect Briefs

Cytotoxic Effects of Four Metallic Oxide Nanoparticles on Dorsal Root Ganglion (DRG) Neurons

Lu S., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University, US

Metallic oxide nanoparticles have diverse industrial applications because of their exploitable physico-chemical and other properties. Consequently, the occupational environmental exposure of humans to these nanparticles is increasing; however, the health impact of their exposure has [...]

Molecular Effects of Silicon Dioxide Nanoparticles on Cell Survival Signaling of Dorsal Root Ganglion (DRG) Neurons and Schwann Cells

Jain A., Jaiswal A.R., Lu S., Wong Y.Y.W., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University, US

The molecular mechanisms underlying the pathophysiology of peripheral neuropathies have not been fully elucidated. To meet the need for suitable cell culture models in vitro of peripheral nervous system (PNS) neural cells that allow long-term [...]

Effects of Silicon Dioxide Nanoparticles on Peripheral Nervous System Neural Cell Models

Jaiswal A.R., Lu S., Pfau J., Wong Y.Y.W., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University, US

Cell model systems in vitro facilitate the high through-put screening of putative toxicity of a variety of nanomaterials, including nanoparticles. However, most of such cell models consisted of non-neural cells. We have developed several central [...]

Differential Cytotoxic Effects of Titanium Oxide Nanoparticles on Peripheral Nervous System Neural Cells

Lu S., Jaiswal A.R., Wong Y.Y.W., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University College of Pharmacy, US

The health impact of exposure to TiO2 nanoparticles is poorly documented although exposure to the particles is known to elicit inflammatory responses in lung tissue. We recently found treatment with TiO2 micro- or nanoparticles induce [...]

Cytotoxicity of metallic oxide nanoparticles in human neural and non-neural cells

Lai J.C.K., Lai M.B., Jandhyam S., Dukhande V.V., Bhushan A., Daniels C.K., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University College of Pharmacy & Biomedical Research Institute, US

The use of nanomaterials in industrial applications (e.g., drug delivery, additives to drugs and cosmetics) has escalated in the last decade, leading to the possibility of their becoming environmental pollutants. However, these cytotoxic and other [...]

Characterization of DNA Transport through a Semipermeable Membrane with the Effect of Surfactants

Leung S.W., Bartolin S., Daniels C.K., Lai J.C.K., Idaho State University, US

In current advances of biotechnology, various models of introduction of DNA into cells to alter their gene expression have important biomedical and bioengineering applications. However, the molecular mechanisms underlying how DNA’s cross cell and nuclear [...]

Differential Cytotoxicity of Metallic Oxide Nanoparticles in Mammalian Cells

Lai J.C.K., Lai M.B., Jandhyam S., Dukhande V.V., Bhushan A., Daniels C.K., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University, US

Nanomaterials have been increasingly used in industrial applications (e.g., drug delivery, additives to drugs and cosmetics). Because of their wide use, occupational exposure to nanomaterials and nanoparticles may pose as health risks. Recent studies have [...]

Silicon Dioxide Nanoparticles Exert Dissimilar Cytotoxic Effects on Mammalian Cell Types

Jandhyam S., Lai J.C.K., Lai M.B., Dukhande V.V., Bhushan A., Daniels C.K., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University, US

Applications of nanomaterials (e.g., silicon dioxide (SiO2) nanoparticles) are ubiquitous. Thus, environmental and occupational exposure to these nanoparticles could pose potential health risk. SiO2 microparticles are toxic in animals in vivo and SiO2 nanoparticles are [...]

Cytotoxic Effects of Short Multi-wall Carbon Nanotubes

Agharkar V.A., Bhushan A., Lai J.C.K., Daniels C.K., Idaho State University, US

The applications of carbon nanotubes (CNTs), a novel and important class of nanomaterials, can change paradigms of various research areas. Although biomedical applications of CNTs are increasing, their putative cytotoxicity has not been substantially addressed. [...]

Silicon Dioxide Nanoparticles Can Exert Cytotoxic Effects on Neural Cells

Lai J.C.K., Lai M.B., Lai J.C.K., Lai M.B., Edgley K.L., Bhushan A., Dukhande V., Daniels C.K., Leung S.W., Idaho State University, US

The health risk and cytotoxic effects of nanoparticles are almost unknown. Consequently, we have launched an interdisciplinary research program to systematically investigate the toxicity of nanoparticles. An initial observation prompted us to hypothesize that SiO2 [...]