Chatterjee D.K. – TechConnect Briefs

Upconverting nanoparticles for in vitro and in vivo cellular imaging

Chatterjee D.K., Zhang Y., National University of Singapore, SG

Conventional fluorescent labels are of limited in vivo utility because short-wavelength radiation penetrates tissues poorly and excites strong background autofluorescence. Upconversion nanoparticles (UCN) convert low-energy exciting photons to visible emissions, resulting in deep tissue penetration [...]

Upconverting nanoparticles for photodynamic therapy

Chatterjee D.K., Zhang Y., National University of Singapore, SG

Photodynamic therapy involves killing of diseased cells by excitation of photosensitizer chemicals with high energy light to produce cytotoxic oxygen species from surrounding dissolved oxygen. However, poor tissue penetration of high energy light and hydrophobic [...]