Cavaliere C. – TechConnect Briefs

Exploiting the “protein corona effect” for targeted drug and gene delivery

Caracciolo G., Pozzi D., Capriotti A.L., Cavaliere C., Cardarelli F., Salomone F., Laganà A., Sapienza University of Rome, IT

When administered in vivo lipid nanoparticles (NPs) are immediately covered by a rich protein layer, known as “protein corona” that changes the size, aggregation state, and interfacial properties of the NP, giving it a biological [...]

Cancer cell targeting of lipid gene vectors by protein corona

Caracciolo G., Pozzi D., Capriotti A.L., Cavaliere C., Cardarelli F., Bifone A., Laganà A., Sapienza University of Rome, IT

We investigated the compositional evolution of the protein corona of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) cationic liposomes (CLs) that efficiently deliver DNA in a wide variety of cell lines as a function of increasing human plasma (HP) [...]