Bifone A. – TechConnect Briefs

Cancer cell targeting of lipid gene vectors by protein corona

Caracciolo G., Pozzi D., Capriotti A.L., Cavaliere C., Cardarelli F., Bifone A., Laganà A., Sapienza University of Rome, IT

We investigated the compositional evolution of the protein corona of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) cationic liposomes (CLs) that efficiently deliver DNA in a wide variety of cell lines as a function of increasing human plasma (HP) [...]

Surface Functionalized Multicomponent Envelope Type Nanosystems for Improved Gene Delivery

Pozzi D., Orlando V., Augusti Tocco G., Biagioni S., Cardarelli F., Bifone A., Caraccioloa G., Sapienza University of Rome, IT

Recently, a new programmed packaging strategy in which various “soft devices” that control intracellular trafficking are incorporated into single nanoparticles has been proposed. Here we apply such a novel concept to develop multicomponent envelope-type nanosystems [...]