University of Manchester – TechConnect Briefs

Characterisation of THP-1 macrophages as an in vitro model for CD44-targeted therapies

M. Rios de la Rosa J., Tirella A., Gennari A., Tirelli N., University of Manchester, UK

CD44 is the major cell surface receptor of hyaluronic acid (HA) and mediates the response of cells to their cellular microenvironment. Whereas the standard isoform (CD44s) is ubiquitously expressed throughout the body, variant isoforms (CD44v) [...]

HA-decorated nanoparticles as tumour-targeting nucleic acids carriers

Tirella A., Rios J.M., Tirelli N., University of Manchester, UK

The design of tools that allow for a targeted delivery of therapeutic cargos have a great potential in the treatment of many pathological conditions (e.g. cancer and autoimmune diseases). In the context of nucleic acids [...]

Investigation of interaction between graphene and steel using Raman Spectroscopy

Fushiwaki Y., Abdelkader A.M., Young R.J., University of Manchester, UK

The purpose of this study is to understand interaction between graphene and sheet steel by the use of Raman Spectroscopy. First of all, the graphene was put on the polished steel. Secondly, it was inspected [...]

Hybrid bionanomaterials based on nanocrystalline TiO2 and catechol-grafted polymers: the effect of composition and morphology on photo and bioactivity

Cellesi F., University of Manchester, UK

We proposed a synthetic strategy for producing hybrid bionanomaterials based on nanocrystalline TiO2 and catechol-grafted polymers. A sol-gel process in organic solvent was developed to grow TiO2 nanocrystals of highly controlled size and surface chemistry, [...]

Structure Development in Flexible Polyurethane Foam Nanocomposites

Stanford J.L., Cookson P.A., Fithriyah N.H., Wilkinson A.N., University of Manchester, UK

This research involves in situ studies on the development of molecular and morphological structures during the processing of flexible, water-blown polyurethane foams containing layered silicate (montmorillonite) nanoparticles. Such materials possess enhanced mechanical properties combined with [...]

Evaluation For The Current Management of Pompe Disease

Khan U.A., University of Manchester, UK

Pompe disease in an autosomal recessive inherited condition characterised by deficiency of the enzyme acid -glucosidase. This causes accumulation of glycogen in muscles, significantly in the heart. The affect is a progressive muscle dysfunction, leading [...]