Tokyo Institute of Technology – TechConnect Briefs

Biodegradable Polymer-Based Composite Particles for Targeted Drug Delivery Carriers with Magnetic Response

Kitamoto Y., Oka C., Ushimaru K., Tsuge T., Horiishi N., Tokyo Institute of Technology, JP

Core–shell composite particles with biodegradability and magnetism were prepared for targeted drug delivery based on magnetic guidance. The composite particles were composed of a core of biodegradable polymer and a shell of assembled magnetic iron [...]

DNA Mechanical Properties: Formulation and comparison with experiments

Dalir H., Nisisako T., Yanagida Y., Hatsuzawa T., Tokyo Institute of Technology, JP

The DNA molecule is the primary genetic material of most organisms. It is a double-helical biopolymer in which two chains of complementary wind around a common axis to form a double-helical structure. This paper aims [...]

Limitations of DNA High-frequency Anchoring and Stretching

Dalir H., Nisisako T., Endo T., Yanagida Y., Hatsuzawa T., Tokyo Institute of Technology, JP

The manipulation of molecules is a crucial prerequisite for the emerging field of molecular nanobiotechnology. This paper reports measurements that characterize the immobilization of 48 kilobase-pair lambda DNA onto lifted-off microelectrodes by high-voltage and high-frequency [...]

Evaluation of Manipulation Probes for Expanding the Range of Capillary Force

Obata K.J., Saito S., Takahashi K., Tokyo Institute of Technology, JP

It is difficult to manipulate a micro-sized object precisely with conventional tools, because the gravity effect becomes extremely small compared to the adhesional one. Therefore, in order to perform reliable micromanipulation, we need to use [...]

A Micromanipulation Method based on the Capillary Force by Phase Transition

Katsuda O., Saito S., Takahashi K., Tokyo Institute of Technology, JP

The size of an object has decreased in the electrical and mechanical engineering field for fabricating highly functional microelectro-mechanical systems and photonic crystals. In micromanipulation, even if we can pickup micro-objects, it is very difficult [...]

Ca-Mg Phosphate Nano-Crystals for High Efficiency Gene Delivery and Expression in Mammalian Cells

Chowdhury E.H., Akaike T., Tokyo Institute of Technology, JP

Significant efforts are now being made for the development of non-viral gene-delivery techniques as alternatives to the viral vectors for basic research and clinical medicine. Despite existence of a wide variety of non-viral techniques particularly [...]

pH-Sensitive Nano-Crystals of Carbonate Apatite Regulate Delivery and Release Kinetics of DNA for Efficient Expression in Mammalian Cells

Chowdhury E.H., Akaike T., Tokyo Institute of Technology, JP

The completion of whole human genome sequencing encourages the development of a powerful gene delivery technology for elucidating structure, regulation and function of genes and proteins in addition to the emerging biomedical applications, such as [...]

Single-Dot Spectroscopy of Low Density GaAs Quantum Dots Grown by Modified Droplet Epitaxy

Yamagiwa M., Minami F., Koguchi N., Tokyo Institute of Technology, JP

Low density GaAs/AlGaAs quantum dots (QDs) have been fabricated using Modified Droplet Epitaxy (MDE) [1] for the spectroscopic study of single QDs using microphotoluminescence (µPL). In µPL measurements, the excitation/observation area is focused by a [...]

Mechanical and Electronic Properties of Nanoscale Semiconductors Studied by Density Functional TB and Path Probability Methods

Masuda-Jindo K., Hung V-V, Kikuchi R., Tokyo Institute of Technology, JP

The atomic and electronic structures of semiconductor heterostructures including steps, misfit dislocations and interface disorder are studied by using the density-functional tight-binding (TB) method. Atomic structures of misfit dislocations both edge type 1/2 (001) and [...]

Criterion for Electrostatic Detachment of an Adhering Microparticle

Saito S., Himeno H., Takahashi K., Onzawa T., Tokyo Institute of Technology, JP

During micromanipulation, the influence of gravitational force becomes extremely small. The adhesional force is more significant for smaller objects. An adhered object can be detached by electrostatic interaction. In our earlier study, the electrostatic force [...]