N.N.Blokhin Russian Cancer Research Center of RAMS

Preparation and investigation of biological activity of thermosensitive liposomes loaded with doxorubicin

Tazina E.V., Polozkova A.V., Orlova O.L., Ignatieva E.V., Mescherikova V.V., Wainson A., Yarmonenko S.P., Oborotova N.A., N.N.Blokhin Russian Cancer Research Center of RAMS, RU

Purpose: Preparation of thermoliposomes with doxorubicin and investigation of their effect on solid Ehrlich carcinoma and B-16 mouse melanoma in combination with hyperthermia. Materials and methods: Thermosensitive liposomes were prepared using DPPC, DSPC, DSPE-PEG 2000 [...]

New efficient nanostructural near-IR photosensitizer for photodynamic therapy of malignancies based on micellar dispersion of zinc octa-4,5-decylthio-3,6-chloro-phthalocyanine

Meerovich G.A., Meerovich I.G., Meerovich G.A., Meerovich I.G., Lukyanets E.A., Negrimovsky V.M., Barkanova S.V., Zorin A.A., Umnova L.V., Oborotova N.A., Loschenov V.B., Vorozhtsov G.N., Baryshnikov A.Yu., N.N.Blokhin Russian Cancer Research Center of RAMS, RU

The work is devoted to investigation of new nanostructural photosensitizer on a base of zinc octa-4,5-decylthio-3,6-chloro-phthalocyanine solubilized in micellar dispersion. Photosensitizer possesses its absorption maximum at about 730 nm and can be considered promising for [...]