CSIRO – TechConnect Briefs

Layered Quantum Dot based Chromogenic Membranes for pH Sensing

Cole I.S., Trinchi A., Hardin S.G., CSIRO, AU

The development of inexpensive, flexible, robust pH sensors with an optical mode of operation remains a key challenge. Monitoring pH is a critical capability, and in most lab applications is carried out using the electrochemical [...]

Computational Design of Inhibited Primers

Cole I.S., Sapper E., Chu C., Breedon M., Chen F., CSIRO, AU

This paper reports on the development of computational design of inhibited primers. It is based on a platform that links models from the molecular scale to the engineered object scale ( airplanes). The platform stores [...]

Reverse Thermoresponsive Polymers for Sustained Delivery of Therapeutic Agents

Mayadunne R., Balachandra A., Gunatillake T., Lindall C., CSIRO, AU

CSIRO has developed thermoresponsive polymers for encapsulation and sustianed release of bioactives. They are stable aqueous solutions over 24 months, easily pass through a 25 gauge needle at room temperature and immediately gel into a [...]

HDCR: A novel method for the diagnostic detection of methylated DNA for blood based cancer diagnostics

Molloy P., Rand K., Ho T., Lindall C., CSIRO, AU

We have developed a novel technique for specific amplification of rare methylated DNA fragments in a high background of unmethylated sequences that avoids the need of bisulphite conversion. The methylation-dependent restriction enzyme GlaI is used [...]

Gold Nanoparticle Chemiresistors as a Generic Platform for Sensing

Chow E., Raguse B., Wieczorek L., Cooper J.S., Hubble L.J., Webster M.S., Müller K.-H., CSIRO, AU

Thiol-functionalised gold nanoparticle chemiresistors can respond to low-molecular weight chemicals through changes in electrical resistance. This low-cost sensor technology is currently being developed for multiple applications including water quality, microbial metabolomics, environmental monitoring, and point-of-care [...]

RAFT Polymerisation for delivery of bioactives

Chiefari J., CSIRO, AU

The RAFT (Reverse Addition-Fragmentation chain Transfer) process is a ground breaking technology that offers unprecedented control over the composition, functionality and architecture of polymers. The versatility of the RAFT technology provides enormous potential for designing [...]

RAFT: A smarter way to develop multi-functional polymers

Chiefari J., CSIRO, AU

The RAFT (Reverse Addition-Fragmentation chain Transfer) process is a ground breaking technology that offers unprecedented control over the composition, functionality and architecture of polymers. The versatility of the RAFT technology provides enormous potential for designing [...]