Auburn University – Page 3 – TechConnect Briefs

Phage Probes for Cancer Diagnostic and Treatment

Samoylova T.I., Morrison N.E., Cox N.R., Auburn University, US

Phage display is a powerful discovery tool with a variety of applications including identification of peptides that specifically recognize and bind to cell-surface targets. Phage particles carrying such peptides have the potential to serve as [...]

Reversible Formation of Silver Nanoparticles in Poly(vinyl alcohol)-Based Thin Films via Electrochemical Switching

Black J.R., Cammaratta V., Gaddy G.A., Slaten B.L., Mills G., Auburn University, US

Ag particles with nanometer dimensions were generated reversibly in the presence of air within micron-thick polymer films using electrochemical techniques.

Phage-Derived Bioselective Nanovehicles for Drug and Gene Delivery

Petrenko V.A., Auburn University, US

Phage display technology rests on two fundamental concepts: combinatorial chemistry and fusion phage. We first demonstrated fusion of the major coat protein of the phage with foreign random peptides, which results in landscape phage libraries. [...]

Simultaneous Detection of Salmonella typhimurium and Bacillus anthracis Spores Using Phage-Based Magnetoelastic Biosensors

Huang S., Yang H., Johnson M., Chen I., Petrenko V.A., Chin B.A., Auburn University, US

Deliberate contamination of the food supply has become a concern, Salmonella typhimurium and Bacillus anthracis spores being primary pathogens of interest. The objective of this research was to investigate simultaneous detection of these two biological [...]

Photogeneration Kinetics of Ag Nanoparticles in Light Sensitive Polymer Films

Korchev A.S., Foti K., Sartin M., Slaten B.L., Gale W., Mills G., Auburn University, US

Ag nanoparticles were generated within light-sensitive films composed of poly(ether ether)ketone, SPEEK and poly(vinyl alcohol), PVA. The benzophenone (BP) groups of SPEEK act as sensitizers; excited states of these functions abstract H-atoms from PVA forming [...]

Investigation of the Deformation Mechanics in Nanoindenter Deflected Freestanding Submicron Gold Thin Films

Wang L., Prorok B.C., Auburn University, US

The Membrane Deflection Experiment (MDE) was employed to perform the microscale tensile testing on freestanding thin films of various FCC metals. Process parameter adjustments and annealing were performed to modulate the film microstructure. High-resolution SEM, [...]

Physics and Modeling of Noise in SiGe HBT Devices and Circuits

Niu G., Auburn University, US

This paper gives an overview of the physics and modeling of noise in SiGe HBT devices and circuits, including RF broadband noise, low-frequency noise, and oscillator phase noise. The ability to simultaneously achieve high cutoö [...]

Computational Modeling of a Piezoelectrically Actuated Microvalve for the Control of Liquid Flowrate

Saeidi S.M., Khodadadi J.M., Johnson C.A., Lee C., Yang E.H., Auburn University, US

Computational modeling of liquid flow in a piezoelectrically actuated microvalve is discussed. A 3-D structured mesh with 330,000 hexahedral cells that represents the major features of the microvalve was generated for the numerical model. Due [...]

Nanofabrication of Bioselective Materials using Diverse Nanolandscapes Displayed on Live Viruses

Petrenko V.A., Olsen E.V., Sykora J.C., Kouzmitcheva G.A., Sorokulova I.B., Brigati J.R., Chen I-H., Chin B.A., Vodyanoy V.J., Auburn University, US

Filamentous phage, such as fd used in this study, are thread-shaped bacterial viruses. Their outer coat is a tube formed by thousands equal copies of the major coat protein pVIII (Figure 1, left). We constructed [...]

Formation of Nanoparticles of a Hydrophilic Drug using Supercritical CO2 and Microencapsulation for Sustained Drug Release

Thote A.J., Gupta R.B., Auburn University, US

The problem of initial burst release, in sustained drug delivery devices was resolved by reducing the active pharmaceutical ingredient particle size by using Supercritical Antisolvent technique with Enhanced Mass-transfer (SAS-EM)., Encapsulation was performed using a [...]