US – Page 234 – TechConnect Briefs

Carbon Nanotube Array Sensor for MEMS Lab-on-a-chip

Joseph L.B., Veedu V., Garmire D., Oceanit and University of Hawaii, US

Lab-on-a-chip devices have the potential to provide point-of-care diagnostics that can save many thousands of lives per year. One of the primary limitations to wide-spread adoption of lab-on-a-chips is the excessive cost of fabrication and [...]

Development of a Flow-cell System to Quantify Analyte-receptor Binding Kinetics Utilizing Guided-mode Resonance Sensors

Wawro D., Zimmerman S., Ding Y., Magnusson R., Moss E., Michalik J., Resonant Sensors Incorporated, US

A novel flow-cell system integrated with a guided-mode resonance sensor element array is presented. The association/disassociation binding cycle is monitored for protein-protein and protein-cell interactions. The real-time binding interactions of the antibody IgG and protein-A [...]

Force Discrimination for Enhanced Biosensor Specificity of Micro-Retroreflector Assays

Knoop J.D., Kemper S.M., Sherlock T., Cacao E., Ruchhoeft P., Willson R.C., University of Houston, US

In nearly all diagnostic/bioanalytical methods other than mass spectrometry, what is actually detected is a label of some sort, and the sensitivity and simplicity of detection of this label limits assay performance. Non-specific interactions between [...]

Identification of bacterial drug resistance in blood

Kaittanis C., Nath S., Perez J.M., University of Central Florida, US

Development of antibiotic resistance by microorganisms has been on the rise in recent years. Therefore, identifying drug resistant strains and effective antibiotic agents is critical. Traditional microbiological methods assess antimicrobial susceptibility within 24 to 48 [...]

Multiple drugs of abuse test for saliva specimen on a single lab-on-a-film-chip using electrochemical immunoassay

Kim Y.H., Park J.H., Nam H.H., Choi M.H., Jung S.H., Song G.J., Nano-Ditech Corporation, US

A novel diagnostic electrochemical immunoassay device integrating lab-on-a-film-chip (LOFC) and microfluidic technologies with chromatographic methods of rapid immunoassays for In Vitro Diagnostics (IVD) has been developed. This LOFC device is produced by a lithography technique [...]

Nanotoxicity Assessment toward the Applications of Carbon Nanotubes as a Small Biomolecule Carrier in Drug Delivery Systems

Sharma A., Sharma R., Kwon S., Baktur R., Sharma A., Sharma R., Utah State University, US

Carbon Nanotube (CNT) materials has superior properties in electric current carrying capacity, thermal conductivity, and thermal stability. Due to their structure with high aspect ratio, they have structural unusual toxicity and complicate safety issue in [...]

Inhibitory Effects of Gold and Silver Nanoparticles on RSV Studied by Atomic Force

Boyoglu S., Vig K., Pfendt A., Pillai S., Willing G.A., Singh S.R., Alabama State University, US

Human Respiratory Syncytial Virus (RSV) causes severe lower respiratory tract infections in infants which may progress to pneumonia. RSV accounts for approximately 4,500 deaths and 90,000 hospitalizations in infants and children in the United States [...]

Silver Coated Carbon Nanotubes Inhibit RSV Infection

Adiani L., Subbarayan P., Boyoglu S., Vig K., Pillai S., Rangari V., Singh S.R., Alabama State University, US

Respiratory Syncytial Virus (RSV) is a member of the genus Pneumovirus in the family of Paramyxoviridae. It is one of the most common causes of upper and lower respiratory tract infections, bronchiolitis and pneumonia worldwide [...]

Respiratory Syncytial Virus Inhibition by Gold and Titanium Nanoparticles

Vig K., Boyoglu S., Rangari V., Pillai S., Singh S.R., Alabama State University, US

Respiratory Syncytial Virus (RSV) is the leading cause of severe respiratory illnesses including bronchiolitis and pneumonia in young children. The RSV surface proteins F (fusion) and G (attachment) are major targets for vaccine development against [...]

Cytotoxicity of metallic oxide nanoparticles in human neural and non-neural cells

Lai J.C.K., Lai M.B., Jandhyam S., Dukhande V.V., Bhushan A., Daniels C.K., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University College of Pharmacy & Biomedical Research Institute, US

The use of nanomaterials in industrial applications (e.g., drug delivery, additives to drugs and cosmetics) has escalated in the last decade, leading to the possibility of their becoming environmental pollutants. However, these cytotoxic and other [...]