US – Page 233 – TechConnect Briefs

Thermoresponsive Magnetic Micelles for Simultaneous Magnetic Hyperthermia and Drug Delivery

Kim D-H., Elena R., Rajh T., Bader S.D., Novosad V., Argonne National Laboratory, US

Hyperthermia has been shown to be a potentially effective therapeutic modality in cancer treatment as it intensifies the efficacy of chemotherapy. The hyperthermia has a good synergic effect with chemotherapy. Their sensitivity to chemotherapy after [...]

Incorporation of Nanoparticles into Soy-based Polyurethane Foam

Liang K., Mao A., Shi S.Q., Mississippi State University, US

Nanotechnology is one of the most effective ways to develop advanced materials. Nanophases including nanoclay, Polyhedral Oligomeric Silsequioxane (POSS), organic and inorganic nanofibers are often used to be incorporated into polymer resin systems to improve [...]

Colloidal apatite nanoparticles exhibiting luminescence and magnetic susceptibility

Nickel A., Prakash K.H., Pedulla M., Kumar R., Montana Tech, US

Hydroxyapatite (HA) has been recognized for some time as a potential candidate for engineering hard-tissue replacements and drug and gene delivery systems. However, the inability to collidally disperse nano-HA (nHA), and perhaps create primary nHA [...]

Nanocomposites based on Self-assembly of Collagen with DNA

Yadavalli V.K., Pidaparti R.M., Virginia Commonwealth University, US

Collagen is a fibrous protein that undergoes a complex self-organizing process at the nano-, micro-, and macro-scales to form hierarchical fibers. Fiber nano/microstructures are extremely sensitive to biophysical/biochemical environments. Their mechanical properties and anisotropy (macroscale) [...]

Fluorescence Based Specific PNA-DNA Binding Characterization on nano-FET DNA Device Surface

Rastogi S.K., Mishra N.N., Finaloski B., Cameron E., Maki W., Postdoc Researcher, US

A novel sequence of peptide nucleic acid (PNA; beta-Ala-(T10)-beta-Ala-NH2) containing ten thymine monomers and beta-alanine amino acid at both (C and N) terminal of main chain was synthesized manually using solid phase tBoc peptide chemistry. [...]

Label-free direct detection of analytes from optically inaccessible samples

Brousseau L.C., Quantum Logic Devices, US

Fluorescent optical methods for biomolecular detection are widely used for research and diagnostic applications. However, these techniques are useful only in sample matrices that are optically transparent non-scattering, which precludes most biologically relevant fluids, such [...]

Performance Comparisons of Nanoparticle Modified Sensor Electrodes for the Detection of Nitrite and Peroxide

Lai J.C.K., Wang Y., Gao W., Gu H., Leung S.W., Idaho State University, US

For the third generation of biosensor that electrode is coupled directly with enzymes, the response time for detection is rapid but stability of the measurements and the coupled enzymes is a concern. In our research [...]

Real-time single-molecule dynamics observed with a nanoscale transistor

Brousseau L.C., Quantum Logic Devices, US

Direct observation of single molecular reactions and motions are impossible by optical techniques due to diffraction limits. However, ensemble measurements of binding dynamics in biological systems offer limited understanding of individual actors in metabolic and [...]

Characterization and Applications of Modified Gold Electrode Sensor with Nanoparticles

Leung S.W., Wang Y., Gu H., Lai J.C.K., Idaho State University, US

In the recent development of biosensor, response time of the sensor is drastically improved by using direct coupling of enzymes onto the surface of electrode. The drawback of the direct coupling of enzymes is denature [...]

Portable FRET Sensing of Proteins, Hormones, and Toxins Using DNA Aptamers and Quantum Dots

Jackson G.W., Strych U., Frank E., Willson R.C., Ballerstadt R., McNichols R.J., BioTex, Inc., US

There is an urgent need to develop methods and devices that make the monitoring of any compound of interest in the public water system more reliable, more sensitive and more economical. We are developing a [...]