Hybrid Nanoparticles Targeted by Antitumor Antibodies and Emitting Alpha-particles

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We describe a new therapeutic nanoparticle’s design, which consists of three parts: targeting, effecter and linker. Targeting part: an anti-HER2/neu mini-antibody-barnase fusion protein (4D5 scFv-barnase-His5). The anti-HER2/neu mini-antibody could be used to deliver barnase to [...]

Preliminary studies of new photosensitizer for photodynamic treatment of melanoma based on nanostructural forms of Bacteriochlorin p N-alkoxycycloimide alkoxyoxyme methyl ester

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This work is devoted to investigation of Bacteriochlorin p N-alkoxycycloimide alkoxyoxyme methyl ester which possesses its absorption band at 795-800 nm. We have estimated the applicability of PDT with this photosensitizer to treat melanoma. We [...]

Contrasting agent for magnetic resonance imaging based on nanostructural dispersion of Manganese derivative of phthalocyanine: preliminary investigation results

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Contrast agents (CA) are used to increase tumor contrasting in magnetic resonance imaging (MRI). The work is devoted to estimation of Manganese chloride tetra-3-phenylthio-tetra-5-tert-buthylphthalocyanine [3-(PhS)4-5-(t-Bu)4PcMnCl] as potential CA for MRI. We have developed the micellar [...]

Optical chemical sensors on the base of arrays of ink-jet printed micro- and nanoparticles

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Array-based optical chemical sensors is a topic of growing interest for researchers. The main advantage of such systems is the possibility of optimizing the performance of sensor array by means of “tuning” individual sensor elements. [...]