Rapier C.E., Chen E., Liu W.F., Lee A.P.
University of California Irvine, US
Keywords: anti-inflammatory, immunomodulatory, microfluidics, particles, PLGA, stent
Biodegradable/bioabsorbable materials are a relatively new movement in the implantable medical device field. Despite the promise of non-permanent implants, bioabsorbable materials can induce a localized inflammatory immune response. To overcome this limitation, we are combining the bioabsorbable property of PLGA and the anti-inflammatory property of an immunomodulatory protein. We are using a microfluidic system designed to conjugate functionalized proteins to PLGA, forming protein-polymer hybrid particles. In the future, we hope to create vascular stents with this anti-inflammatory PLGA material which would provide a non-permanent, biodegradable alternative to conventional stent materials.
Journal: TechConnect Briefs
Volume: 3, Biotech, Biomaterials and Biomedical: TechConnect Briefs 2015
Published: June 14, 2015
Pages: 246 - 248
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topic: Biomaterials
ISBN: 978-1-4987-4729-5