Linseed oil miniemulsions stabilized by polyelectrolyte complex (gum arabic-chitosan)

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An linseed oil miniemulsion was optimized using the microfludization process and finally stabilized by polyelectrolyte complexes formation. Emulsion preparation variables such as gum arabic/oil mass ratio (GA/O), oil volume fraction (), homogenization pressure and number [...]

Dex40-GTMAC3, modified dextran as a novel heparin antagonist

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Protamine is the only registered antidote preventing bleeding of patients treated with unfractionated heparin (UFH). However protamine may induce anaphylactic shock or serious hypotension. We aimed to develop an alternative fully synthetic UFH antidote as [...]

Nonclinical evaluation of heparin binding copolymer – HBC1 for restoring of blood coagulation after heparin treatment

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The incredible progress and wide use of various medical devices during intravascular or cardiac interventions increased the need for administration of anticoagulants, such as heparins. Protamine sulfate – a protein isolated from salmons is the [...]