Design of a novel melatonin Pickering emulsion sunscreen

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Melatonin, the main secretory product of the pineal gland, was recently found to have a protection effect against photocarcinogenesis based on its free radical scavenger and antioxidant activity. On the other hand, the daily use of sunscreens is particularly recommended for patients treated with immunosuppressive drugs and submitted to surgeries, chemotherapy and radiotherapy. Therefore, melatonin associated with sunscreens may be the key strategy in order to prevent UV-radiation induced skin damages, such as pre-cancerous and cancerous skin lesions. The aims of this study were the stabilization of melatonin in a novel sunscreen Pickering emulsion and its morphological characterization, droplet size distribution, contact angle and sun protection factor. Melatonin was incorporated in a novel Pickering emulsion Melatonin SunScreen (MSS) using physical UV filters as solid particles. Contact angles, Morphological characterization and Droplet size distribution and SPF were assessed. The formulation obtained showed good cosmeticity and to be of a low irritant nature. Surprisingly, a TiO2-based Pickering emulsion containing suitable excipients provided good results in terms of physical stability and high UV protection. Consequently, it offers an excellent compromise between stability, UV protection and cosmeticity

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Journal: TechConnect Briefs
Volume: 3, Biotech, Biomaterials and Biomedical: TechConnect Briefs 2015
Published: June 14, 2015
Pages: 285 - 288
Industry sectors: Advanced Materials & Manufacturing | Personal & Home Care, Food & Agriculture
Topics: Personal & Home Care, Food & Agriculture
ISBN: 978-1-4987-4729-5