Papers – Page 13 – TechConnect Briefs

Computer Program Simulation of Protein Sturcture and Theory of Mechanic Force for Protein Folding II

Lu K.U., California State University, US

In the previous paper [21], we have worked out the calculation of the coordinates of the atoms in polypeptide chain, and the mathematical procedures for computing the coordinates of atoms of the alpha helices and [...]

Competitive Template Analysis of the Fast Messy Genetic Algorithm When Applied to the Protein Structure Prediction Problem

Day R.O., Zydallis J.B., Lamont G.B., Air Force Institute of Technology, US

The Protein Structure Prediction (PSP) problem is a Grand Challenge problem among biochemists, computer scientists and engineers alike. Solving this problem involves correctly predicting the geometrical conformation of a fully folded protein. This paper focuses [...]

Solving the Protein Structure Prediction Problem Through a Multiobjective Genetic Algorithm

Day R.O., Zydallis J.B., Lamont G.B., Pachter R., Air Force Institute of Technology, US

The Protein Structure Prediction (PSP) problem is a Grand Challenge problem among biochemists, computer scientists and engineers alike. Solving this problem involves correctly predicting the geometrical conformation of a fully folded protein. This paper focuses [...]

Building and Testing Scalable Fuzzy Models of Genetic Regulation in Bacteria

Sokhansanj B.A., Rodrigue G.R., Fitch J.P., Lawrence Livermore National Laboratory, US

Recent technological advances in high-throughput data collection (reviewed in [1]) give biologists the ability to study increasingly complex systems as a whole. One example is the DNA chip or microarray, an efficient high-throughput method for [...]

Stochastic Optimization Methods for Biomolecular Structure Prediction

Herges T., Wenzel W., Institute for Nanotechnology - Karlsruhe, DE

Protein structure prediction (PSP) remains one of the main outstanding challenges of theoretical biophysical chemistry. Its goal is to predict the fully three-dimensional tertiary structure of the protein on the basis of its amino acid [...]

Complex Fluid Dynamics in BioMEMS Devices: Modeling of Microfabricated Microneedles

Liepmann D., University of California-Berkeley, US

MEMS technologies promises to revolutionize health care by providing precise control of biological fluids for both diagnoses and treatments. For example, microneedles can be used for sample collection for biological analysis, delivery of cell or [...]

Modeling and Simulation for MEMS Design, Industrial Requirements

Neul R., Robert Bosch GmbH, DE

The development process of today’s products is dominated by demands like ‘product performance’, ‘quality, ‘time to market’, ‘development cost’, ‘development risk’ etc., while the products’ complexity is increasing. Design methods for MEMS devices are discussed, [...]

What to do with Statistical Mechanics when the Figure of Merit Cannot be Calculated: Library Design for High-Throughput Materials Development

Deem M.W., University of California, Los Angeles, US

By analogy with Monte Carlo algorithms, we discuss new strategies for design and redesign of libraries in high-throughput experimentation, or combinatorial chemistry. Several Monte Carlo methods are examined, including Metropolis, several types of biased schemes, [...]

The Inverse Band Structure Approach: Given the desired electronic property, find the atomic configuration

Zunger A., National Renewable Energy Laboratory, US

Modern crystal-growth techniques, such as molecular beam epitaxy or metal-organic chemical-vapour deposition, are capable of producing prescribed crystal structures, sometimes even in defiance of equilibrium, bulk thermodynamics. These techniques open up the possibility of exploring [...]

The Number of Human Genes and Proteins

Davison D., Bristol-Myers Squibb, Pharmaceutical Research Institute, US

The definitive prototype for nanotechnology is the cell. Its many machines and exquisitely controlled internal and external movements are a reference for all researchers working in the field. The complete instructions for every molecular machine [...]