Topic: Biomaterials
Magnetic drug targeting using concept of focused magnet
Jancurova L., Timko M., Bano M., Koneracka M., Repasan M., Kopcansky P., Technical University, Faculty of Electrical Engineering and Informatics in Kosice, SK
Current research on methods to target chemotherapy drugs in the human body includes the investigation of biocompatible magnetic nano-carrier systems, e.g. magnetic liquids such as ferrofluids. The aim of our work was to construct a [...]
Chitosan as mucoadhesive agent to enhance absorption of therapeutic proteins encapsulated into solid lipid nanoparticles
Teixeira J., Júlio A., Castro C., Fonseca J., Martins S., Ferreira D., Sarmento B., University of Porto, PT
The aim of this work was to develop Witepsol 85E solid lipid nanoparticles (SLN) containing insulin as biopharmaceutical, and to evaluate their potential for oral insulin administration. The new carrier was coated with chitosan in [...]
Novel Cleavable PEGylated Liposomes for Enzyme Triggerable Release of Nucleic Acid in Tumours
We have developed a dePEGylation approach based on the activity of the proteolytic enzymes that are associated with tumour cells. The elevated enzyme activity facilitates the extravasation of the cells by degrading the extracellular matrix [...]
Action of Paclitaxel pH-Sensitive Liposomes on B16F1 Melanoma Cells
Long circulating pH-sensitive liposomes loaded with Paclitaxel were developed and characterized for the encapsulation efficiency, release characteristics and its action on B16F1 melanoma cells (low metastatic). Paclitaxel loaded pH-sensitive liposomes showed better release pattern and [...]
Fashioning of Polymer Multi-functional Nanovector Microparticle Delivery System by High Definition Microextrusion
Gabriele P.D., Hogan A., D’Ottavio J., Flemmens M., Weir M., ARmark Authentication Technologies, LLC, US
Considerable advances have recently been achieved in the development of nano-scale particles for cancer diagnostics and therapies. ARmark Authentication Technologies, LLC has developed a new technology platform to produce stable multifunctional polymeric microcarrier delivery vehicles [...]
Microparticles on the Basis of Segmented Polyurethanes for the Treatment of Tuberculosis
The objective of the research is to develop a new drug delivery system based on polyurethane microparticles for the treatment of tuberculosis by pulmonary administration to the lungs. The synthesis and characterization of polyurethane microcapsules [...]
Newer Methods of Nanoparticle Synthesis: Nitroimidazole properties with Nanometal oxides in Polymer Cages
Nitroimidazoles are radiosensitizers and hypoxia detecting chemosensitizers. Intially nitroimidazoles were single dose antibiotic drugs. Recently, nitroimidazole derivatives have emerged as multifunctional “drug-biomarker monitors” chemical compounds with importance in treatment of tumors, monitoring hypoxia and safer [...]
Mechanism of Nitroimidazole Coated Magnetic Nanoparticles Embedded in Micro-organisms as Delivery Systems
Avirulent Bacteria and parasites act as “tiny missile like carriers” capable to carry the magnetic nanoparticles (NMP) together with anticancer or radiosensitizer drugs at the tumor site. We compared the iron-oxide particles binding characteristics with [...]