Topic: Biomaterials
Controllable Preparation of 10 nm Solid Lipid Nanoparticles based on Phase Behaviors of Drug-Loading Hot Microemulsions
A new method was presented for controllable preparation of 10-nm-scale drug carriers based on the phase behaviors of hot microemulsions. This method is suitable for preparation of nanodrug of many water insoluble drugs.
Protein Nanoparticles
Protein nanoparticles can be utilized for the pulmonary delivery of protein therapeutics or can be incorporated into biodegradable polymer microspheres/nanospheres for controlled release depot or oral delivery. With proteinaceous therapeutics, the generation of nanoparticles is [...]
Enhanced Gene Delivery Efficiency in Resonant Acoustic Fields
Enhancement of DNA delivery efficiency has been improved by several physical and chemical approaches in the past decade. However, the application of those methods is hampered by large-scaled configurations. To augment gene delivery efficiency with [...]
Nano-structured Chitosan Self-Aggregates as a Drug Delivery Carrier
A number of novel delivery systems have been developed including the entrapment of drugs, proteins, antigens, or genes in small vesicles or within polymeric matrices. Colloidal delivery systems such as liposomes, microemulsions, and polymeric micelles [...]
Multi-scale Drug Release Modeling for Targeted Oral Drug Delivery (TODD)
Haddish B.N., Nyquist C., Haghighi K., Wu H.A., Corvalan C., Rickus J., Keshavarzian A., Purdue University, US
Conventional oral dosage forms deliver their active ingredient at rates that are high initially and decline afterward, showing a first order kinetics with the release determining step considered as the dissolution rate of the active [...]
New Highly Efficient Non-invasive Nanoparticulate Delivery Systems for the Treatment of Chronic Diseases
We herein report the overall goals of the joint project “Nano-Health” and preliminary results of two sub-projects (Nano-Health started in October 2004), which was positive evaluated by international reviewers within the first Call of the [...]
Superparamagnetic Iron Oxide Nanoparticles for Multiple Biomedical Applications
Hofmann H., Hofmann M., Petri-Fink A., Steitz B., von Rechenberg B., Hofmann H., Hofmann M., Juillerat J., Swiss Federal Institute of Technology Lausanne, CH
Superparamagneticiron oxide nanoparticles (SPION) were mixed at various ratios with different polymer solutions to obtain SPION coated with PVA modified by functional groups (amino-SPION, carboxy-SPION, and thiol-SPION). Studying human melanoma cells by theses different functionalized [...]
pH-Responsive Hydrogel with Controlled Swelling and Degradation Rate
Trujillo-Lemon M., Bowman C.N., Stansbury J.W., University of Colorado Denver and Health Sciences Center, US
Degradable polymeric materials that can be storage for months in aqueous enviroment before undergoing on-command controlled swelling and degradation were prepared and their kinetics of swelling and degradation were evaluated. The swelling and degradation rates [...]
Carbon Coated Magnetic Nanoparticles for Local Drug Delivery using Magnetic Implants
Fernández-Pacheco R., Ibarra M.R., Valdivia J.G., Marquina C., Serrate D., Romero M.S., Gutiérrez M., Arbiol J., Institute of Nanoscience of Aragon, ES
Bioferrofluid obtained using iron coated nanoparticles are promising candidates for magnetic drug delivery. The carbon cages made the particles biocompatibles and provide a suport for drug adsortion. We propose a new method in which gold [...]