Advanced Materials & Manufacturing – Page 162

Highly sensitive detection of cancer biomarker EGFR by PicoTREC-SERS

Xiao L., Harihar S., Wu Y., Welch D.R., Zhou A., Utah State University, US

It is reported that for women in the U.S., breast cancer death rates are higher than those for any other cancer, besides lung cancer. Considering the fact that approximately 70–80% of breast carcinomas overexpress the [...]

Metastatic diagnosis of colon cancer by vertically aligned carbon nanotube based electromechanical biosensor

Abdolahad M., Taghinejad H., Taghinejad M., Taghinejad H., Taghinejad M., Janmaleki M., Mohajerzadeh S., University of Tehran, IR

vertically aligned carbon nanotube based electrical biosensor was demonstrated as a more rapid, sensitive and specific device for metastatic diagnosis of colon cancer cells based on the mechanical entrapment of metastatic cancer cells on vertically [...]

Bio-imaging of colorectal cancer models using a CK19-bioconjugated Quantum Dot Nanoprobe

Gazouli M., Nikiteas N., Anagnou NP., Kelekis N., Efstathopoulos E., School of Medicine University of Athens, GR

The aim of the study was to develop and validate a QD-nanoprobe for the detection of CK19 protein for in vivo colorectal cancer molecular targeting. QDs with a maximum emission wavelength of 655 nm, were [...]

Isolation and Detection of Cancer Related DNA Nanoparticulate Biomarkers Directly from CLL Patient Blood “Rapid Sample to Sequence Diagnostics”

Heller M.J., Marciniak J., Sonnenberg A., University of California San Diego, US

The analysis of cell free circulating (cfc) DNA biomarkers continues to become more widely used for cancer diagnostics and management. Cfc-DNA ranges from nucleosomes and high molecular weight DNA nanoparticulates to 100-200bp fragments. We have [...]

Effects of Titanium Dioxide Nanoparticles (TiO2) on Behavioral Parameters of Rats

Rihane Ben Younes N., Amara S., Mrad I., Omri K., El Ghoul J., El Mir L., El Ghoul J., El Mir L., Jeljeli M., Ben Rhouma K., Abdelmelek H., Sakly M., Faculty of Sciences, TN

Titanium dioxide nanoparticles (TiO2-NPs) have a wide range of applications in many fields. The effects of TiO2 NPs on the central nervous system are still unclear. The present study, we investigated the effects of sub-acute [...]

Cationic polystyrene nanosphere induces autophagy through inhibition of Akt/mTOR and activation of AMPK signaling pathways in macrophage and epithelial cells

Chiu H-W, Xia T., Tsai J-C, Chen C-W, Wang Y-J, National Cheng Kung University, Medical College, TW

Nanoparticles have been used to produce a wide range of products. Those include applications in imaging and drug delivery in medicine. However, the possible adverse biological effects in human being remain unclear. Autophagy is an [...]

Pharmacokinetics and Safety Studies of Low Molecular Weight Heparin Nanoconjugates

Yang T., Bouchard B., Cook A., Hu J., Hao J., Bai S., Husson University, US

Low molecular weight heparins (LMWHs) have received widespread acceptance as the first choice for initial prevention and treatment of venous thromboembolism via subcutaneous injection one to two times daily in the clinic. The need for [...]

Iron-sequestering molecules play a pivotal role in the mechanism of toxicity of SWNTs on fungal and bacterial cells

Chaves J.S., Chaves S.J., Zuniga P., Chaves J.S., Chaves S.J., Instituto Tecnologico de Costa Rica, CR

In this study we described that iron-sequestering molecules are responsible for the toxicity of iron containing SWNTs to microorganisms. After incubating different concentrations of functionalized SWNTs with bacteria and fungal cells, it was found that [...]

Magnetic Targeting of Human Aortic Smooth Muscle Cells for Rapid Closure and Healing of Intracranial Aneurysm/Pseudoaneurysm

Arias S.L., Alucozai M., Pastrana F., Reece L.M., Kempaiaih R., Pavon J.J., Allain J.P., Purdue University, US

A novel approach is proposed in this study using a magnetic strategy to address the current disadvantages of detachable coils and stent grafts for aneurysm/pseudoaneurysm treatment. It consists of a patch facing the aneurysm neck [...]

Noble metal nanoparticles for plasmonic photothermal therapy of atherosclerosis

Kharlamov A., Gabinsky J., Erasmus University Medical Center, NL

Background: Our previous bench studies PLASMONICS and NANOM First-in-Man trial documented TAV reduction up to unprecedented 79.4 and 60.3 mm3 respectively with high level of safety and feasibility. Methods: The completed randomized two arm (1:1) [...]