Wang L.F., Lo Y.L., Ke J.H.
Kaohsiung Medical University, TW
Keywords: drug delivery systems, magnetic nanoparticles, MRI contrast agents
One-pot synthesized polyacrylic acid-modified iron oxide (PAAIO) was decorated with a polymer, which was served as a reservoir for a therapeutic agent or a fluorescent dye via chemical or physical approaches. PAAIO possess specific magnetic properties upon an exposed magnetic field, which endow them an attractive platform as a contrast agent for magnetic resonance imaging (MRI) and as a carrier for drug delivery systems. In this study, we are going to show some examples using surface-modified PAAIO in biomedical applications such as magnetofection,1 dual-modality nanoprobe, and theragnostics as a scheme shown below. Magnetofection is defined as the delivery of DNA,2 siRNA,3 or nucleic acids associated with magnetic nanoparticles to cells in the application of a magnetic field
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Published: May 12, 2013
Pages: 9 - 12
Industry sector: Medical & Biotech
Topics: Diagnostics & Bioimaging, Sensors - Chemical, Physical & Bio
ISBN: 978-1-4822-0586-2