Radiolabelled Microspheres As a Delivery System For Targetad Radiotherapy


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99mTc(V)DMSA (Dimercaptosuccinic acid) is a well-known radiopharmaceutical for imaging neurogenic tumors. 188Rhenium, a beta radiation emitter with 2.2 MeV energy having half life of 16.9 hours is a therapeutic analogue of imagable 99mTechnetium was introduced for targeted therapy.188Re(V)DMSA encapsulated PLGA microspheres were prepared, using 10% of PVA concentration, by double emulsion solvent evaporation technique. Microspheres of 0.2-2.0 micron were prepared. Re-188(V)DMSA-PLGA microspheres were incubated with cultured Glioma cells (U87MG) for the assessment of in-vitro cell survival.

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Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2008: Life Sciences, Medicine & Bio Materials – Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: June 1, 2008
Pages: 398 - 400
Industry sector: Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery
ISBN: 978-1-4200-8504-4