Panagiotou T., Fisher R.J.
Delphi Scientific, LLC, US
Keywords: continuous manufacturing, emulsification, homogenization, nanoemulsion, scale up
Nanoemulsions find applications across industries, with several pharmaceutical and nutraceutical applications in the market. Delphi Scientific, LLC has developed a methodology to improve large scale nanoemulsion manufacturing by addressing key issues such as high energy demand, lack of repeatability and scalability, and high cost. It includes the following steps: (a) identification of the key processing parameters that affect the formation of a particular nanoemulsion, (b) development of methods to control and scale up such parameters, and (c) design of equipment that is suitable for large scale manufacturing. This methodology was applied to several emulsion formulations. Results indicate that stable nanoemulsions with average particle size as low as 63nm were produced successfully. The homogenization energy requirements were reduced by up to a factor of 2.6 times compared to requirements of conventional methods, while scale-up to several liters per minute bacame attainable.
Journal: TechConnect Briefs
Volume: TechConnect Briefs 2019
Published: June 17, 2019
Pages: 111 - 114
Industry sector: Advanced Materials & Manufacturing
Topics: 3D Printing, Advanced Manufacturing
ISBN: 978-0-9988782-8-7