Karampelas I.H., Alali F., Furlani E.P.
SUNY-Buffalo, US
Keywords: localized surface plasmon resonance (LSPR), LSPR-induced optical absorption, nanocages, photothermal therapy, plasmonic nanobubble cancer treatment, plasmonic nanocages photothermal energy conversion, plasmonic-enhanced photothermal energy transfer, pulsed-laser photothermal heating
A series of new computational models is introduced to demonstrate several photonic and thermo-fluidic details of the photothermal process associated with nanosecond-pulsed, laser-heated gold nanocages. Such models can be used to simulate energy conversion within nanocages of different sizes and shapes at plasmon resonance, heat transfer to the immediate fluid (e.g. for photothermal therapy applications) as well as phase change and homogenous bubble nucleation (e.g. for plasmonic nanobubble cancer treatment). Thus far, we have considered various nanoparticle geometries that exhibit some form of axial symmetry, such as nanorods, nanotori and nanorings. However, modelling nanocages can be numerically more challenging since it requires a full 3D approach. Finally, our work indicates that numerous parameters i.e. pulse duration, laser intensity and nanoparticle orientation can be calibrated for optimal photothermal performance. We discuss the utilization of such nanoparticles in photothermal applications involving drug delivery and therapy of malignant tumors.
Journal: TechConnect Briefs
Volume: 3, Biotech, Biomaterials and Biomedical: TechConnect Briefs 2015
Published: June 14, 2015
Pages: 242 - 245
Industry sector: Sensors, MEMS, Electronics
Topic: Micro & Bio Fluidics, Lab-on-Chip
ISBN: 978-1-4987-4729-5