Organic Nanobiomimetic Memristor/Memcapacitor Devices Ultrasensitive Direct Detect Matrix Matelloproteinase-2 in Human Serum

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Matrix Matelloproteinase-2 (MMP-2) plays a key role in many diseases. A new type of dual-functioning device was developed for fast, direct ultrasensitive detection of MMP-2 using NIST SRM965A reference human serum specimens under label-free, probe-free and reagent-free conditions. The organic memcapacitor/memristor device was based on a self-assembled polymer membrane having polarized 3D array crossing-nanotube structures on a gold substrate that enables selective inducing bio-communication with MMP2. The characteristics of memcapacitor/memristor were observed in the i-V curves of the hysteresis. The Chronoamperometry (CA) method has a Detection of Limits (DOL) value of 8.67×10-18g/mL in PBS solution related to current density between 1.47 µA/cm2 and 919.2 mA/cm2 over MMP2 concentration between 20 ag/mL to 100 ng/mL with a Relative Pooled Standard Deviation 1.4% (n=26). The Double Step Chronopotentiometry (DSCPO) method produced a similar impression value of 1.47% (n=18) over MMP2 concentration 40 ag/mL to 100 ng/mL over energy density between 185 – 0.47 µWHR/cm3. The sensor was able to direct detect MMP2 in pure NIST serum specimens in the concentrations of 81.15 ± 0.10 ag/mL in normal glycemia serum, 1.13 ± 0.0016 pg/mL in hypoglycemia serum and 1.4± 0.0001 pg/mL in hyperglycemia serum, respectively. Multiple factors impacting on the sensor’s energy storage capability were also studied.

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Journal: TechConnect Briefs
Volume: 3, Biotech, Biomaterials and Biomedical: TechConnect Briefs 2017
Published: May 14, 2017
Pages: 271 - 274
Industry sector: Sensors, MEMS, Electronics
Topic: Sensors - Chemical, Physical & Bio
ISBN: 978-0-9988782-0-1