Chen E.T., Thornton J., Ngatchou C., Duh S-H, Kissinger P.T.
Advanced Biomimetic Sensors, Inc., US
Keywords: 3D heat release mapping, electric pulse treatment, nanobiomimetic memristor sensing, ratio of action potential vs. resting potential
Current technology is not available to provide a portable, simple and accurate real-time monitoring and treatment of cancers simultaneously in an early stage at a clinical setting. Challenges for developing such a tool, include the need to develop an advanced sensing technology are paramount. Here we report a memristor sensor device (sensor #1) for timely monitoring and treatment of brain cancers at 5 cell/mL concentration. The purpose of this study is to determine the device’s capability to monitor the heat release at a 5 cell/mL concentration and compare these results with triple-negative (TNA) breast cancer results. The output of our device is a cancer cell heat release map in a 3D format which compares before and after treatment from three short pulses applied to the brain cancer cells in vitro based on a nanostructured memristor sensing technology with cross linked polymer membrane fabricated on gold chips under reagent-free condition as sensor #1 compared with a nanopore sensor #2 which has a selectivity for TNA cancer only. Our results shown the heat reduced by 60, 80 and 100% for sensor #1 compared with -40, 53 and 100% for sensor #2 after first, second and third pulse treatment, respectively
Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2014: MEMS, Fluidics, Bio Systems, Medical, Computational & Photonics
Published: June 15, 2014
Pages: 200 - 203
Industry sector: Medical & Biotech
Topics: Diagnostics & Bioimaging, Sensors - Chemical, Physical & Bio
ISBN: 978-1-4822-5827-1