Fabrication and characterization of core-shell microspheres composed of pectin and arabinoxylans as controlled release systems for insulin

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Currently incidence of diabetes is increasing worldwide very, WHO classifies it as an epidemic (WHO, 2012) and in Mexico is the leading cause of death (IMSS, 2012). The traditional form of insulin subcutaneous injection, is difficult, painful, tedious and sometimes causes withdrawal. Developing new forms of administration is necessary, such as oral administration that targets release and absorption in the colon. Encapsulation of bioactive compounds in polymer matrices protects them problems factors such as pH, enzyme activity, and temperature, preventing deterioration and loss of activity. Due to its characteristics of biodegradability in the colon, and gelling capacity, polysaccharides such as pectin and arabinoxylans, are used as carriers in this study. Electrospray manufacturing was chosen, due to efficieny and non-destructive features. The aim of this work was to fabricate and characterize core-shell micro and nanospheres composite low methoxyl pectin (shell) and ferulated arabinoxylans (core) as insulin carriers by systems, optimizing the production conditions by coaxial electrospray.

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Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2014: MEMS, Fluidics, Bio Systems, Medical, Computational & Photonics
Published: June 15, 2014
Pages: 327 - 330
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery
ISBN: 978-1-4822-5827-1