Madhavan K., Belchenko D., Tan W.
University of Colorado at Boulder, US
Keywords: biocompatibility, collagen, genipin, smooth muscle cell, viscoelasticity
This study involves the mechanical and biological characterization of crosslinked collagen-based scaffolds for arterial medial-equivalent. These scaffolds are made from a mixture of collagen, chitosan and elastin and crosslinked with genipin. The method of optimization of mechanical and biological properties involves the variation of concentration of components (collagen & chitosan) and crosslinker (genipin). Varying the concentration improves the biomimetic mechanical properties. Even though smooth muscle cells and endothelial cells exhibit high biocompatibility to genipin-crosslinked scaffolds, varying the genipin concentration affects the cell ingrowth in these scaffolds. By striking a balance between the mechanical and biological properties, we are able to design a suitable material.
Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2009: Life Sciences, Medicine, Diagnostics, Bio Materials and Composites
Published: May 3, 2009
Pages: 329 - 332
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topic: Biomaterials
ISBN: 978-1-4398-1783-4