Determination of the Electroporation Threshold for pulses from 95 ns to 20 us

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The dependences of the fraction of electroporated mouse hepatoma MH-22A cells on the pulse intensity were obtained for the cells exposed to single square-wave electric pulses with the durations from 95 ns to 20 us. The amplitude of an electric pulse was varied from 0.4 to 12 kV/cm. Increasing the intensity of the electric field pulse increased the fraction of electroporated cells. The electric field which leads to a given percentage of electroporation decreased with increasing the pulse length. The dependence of the amplitude of the electric pulse required to electroporate 50% of mouse hepatoma MH-22A cells on the pulse duration was also determined.

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Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 21, 2010
Pages: 506 - 509
Industry sector: Medical & Biotech
Topics: Biomaterials, Cancer Nanotechnology
ISBN: 978-1-4398-3415-2