A pbpk model to elucidate processes governing distribution and excretion of polyacrylamide nanoparticles

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This paper presents a physiologically based pharmacokinetics model that has been calibrated using experimental measurements of biodistribution and excretion of polyacrylamide nanoparticles in rats. The model is capable of establishing the complete mass balance of nanoparticles, including blood content, excretion, and different locations of accumulation (Organs of the RES, peripheral tissues). It explores the basis for scaling and identify key factors affecting the pharmacokinetics of nanoparticles.

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Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 20, 2007
Pages: 267 - 270
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topics: Biomaterials, Materials Characterization & Imaging
ISBN: 1-4200-6183-6