A Novel Device for In-Vitro Electromagnetic Modulation

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Our in-vitro experiments with cold plasma discharge have demonstrated frequency dependent modulation effects. If a large number of cold plasma discharges with different modulation frequencies can be generated at the same time, the time required to search for an optimal frequency for a given biological effect is correspondingly reduced. Our technology is designed to use a standard 96 well polystyrene micro-plate as a basis for studying modulation frequency dependent electromagnetic effects on bacterial, fungal or viral cultures. A set of up to 96 square wave frequency generators is implemented with a Xilinx Artix-7 FPGA. These signals modulate electrical array elements which sit below each well in the micro-plate. Temperature control of the electrical array also allows culture incubation. The array modules are designed as different options, sharing a common digital controller and power supply design. The controller provides thermoelectric temperature control (heating and cooling), modulation generation and user interface. The user interface is a 2×20 OLED character display with push-button menu options, a memory card for experiment setup, and optional RS-485 MODBUS protocol. A typical experiment may use a large number of modulation array units. There are five different array options: 24 channel cold plasma, 96 channel RF near-field (2.4 GHz), 96 channel electric field (200Vp-p), 96 channel LED (IR, red, blue, UV etc.), and 96 channel magnetic field (vertical ferrite bars with solenoid coils).

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Journal: TechConnect Briefs
Volume: 4, Advanced Manufacturing, Electronics and Microsystems: TechConnect Briefs 2016
Published: May 22, 2016
Pages: 218 - 221
Industry sectors: Advanced Materials & Manufacturing | Sensors, MEMS, Electronics
Topic: Printed & Flexible Electronics
ISBN: 978-0-9975-1173-4