A better biomaterial for bone regeneration: type II collagen


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Type II collagen facilitates osteogenesis and suppresses adipogenesis simultaneously during early stage of MSC differentiation, mediated through the same signaling cascades. Type II collagen-coated plates enhanced BMSC mineralization better than did either non-coated or type I collagen-coated groups. While implanted in the fracture bone of rats, the type II collagen-HA/TCP (nano-particle) scaffold group showed significant faster bone formation at the reunion site, higher SFI scoring of foot-stepping and better locomotion as comparing to that of control group or type I collagen-HA/TCP group did. Collectively, type II collagen serves as an important modulator during early osteogenic differentiation of BMSCs, and enhance bone defect repair through an endochondral ossification-like process. The information advances our understanding about the cartilaginous ECM-BMSC interaction and provides perspective strategies for faster bone regeneration

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Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Published: May 12, 2013
Pages: 343 - 346
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topics: Biomaterials, Cancer Nanotechnology
ISBN: 978-1-4822-0586-2