VEGF – TechConnect Briefs

Cationic Nanoparticles Effectively Delivered VEGF SiRNA in A549 Cells

Yang T., Li X., Liu Y., Liu Y., Bai S., Husson University, US

Recent discovery of small interfering RNA (SiRNA) that silences growth factors appears to improve effectiveness and safety of cancer therapy. Unfortunately, delivery of SiRNA to cancer cells is a major obstacle. Our work is focused [...]

Sirna Nanomedicines for Cancer Gene Therapy

Kim S-H, Park T.G., Korea Advanced Institute of Science and Technology, KR

We developed a polyelectrolyte complex (PEC) micelle-based delivery system for treatment of prostate cancer. A PEGylated siRNA targeting human vascular endothelial growth factor (hVEGF) was synthesized. The hVEGF expression was almost completely inhibited in vitro [...]