Structural Elucidation of Doxorubicin-Loaded Liposomes by Atomic Force Microscopy in air and water
Tian B.W., Al-Jamal W.T., Stuartb M., Kostarelos K., The School of Pharmacy, University of London, UK
Doxil is a clinically used, FDA-approved liposomal product against cancer. Structural elucidation of liposomal doxorubicin by cryogenic-transmission electron microscopy (cryo-EM) showed that doxorubicin (Dox)form crystal-like structures inside liposomes. Since 1992, cryo-EM has been the only [...]