SLN – TechConnect Briefs

Sustained-release liquisolid compacts of lumenfantrine-artemether as alternate-dayregimen for malaria treatment to improve patient compliance

Nnamani P.O., Ugwu A.A., Ibezim E.C., Kenechukwu F.C., Ogbonna J.D.N., Obitte N.C., Chime S.A., Attama A.A., University of Nigeria, Nsukka, NG

Lumenfantrine-SLN (LUM, 0.2, 0.5, 0.8 and 1%w/w)formulated with Precirol-Transcutol (PT) and Tallow fat-Transcutol (TT) at 3:1 contained surfactants (Poloxamer 188, Polysorbate 80 and Solutol HS). PS, ZP, PDI,morphology, EE, interaction study and in vitro drug [...]

Chitosan as mucoadhesive agent to enhance absorption of therapeutic proteins encapsulated into solid lipid nanoparticles

Teixeira J., Júlio A., Castro C., Fonseca J., Martins S., Ferreira D., Sarmento B., University of Porto, PT

The aim of this work was to develop Witepsol 85E solid lipid nanoparticles (SLN) containing insulin as biopharmaceutical, and to evaluate their potential for oral insulin administration. The new carrier was coated with chitosan in [...]