radiopharmaceuticals – TechConnect Briefs

Hybrid Nanoparticles Targeted by Antitumor Antibodies and Emitting Alpha-particles

Resheto I.V., Deev S.M., Chuvilin D.Y., Panchenko V.Y., Sukharev S.S., Streltsova E.A., P.A.Hertzen Moscow Research Oncological Institute (MROI), RU

We describe a new therapeutic nanoparticle’s design, which consists of three parts: targeting, effecter and linker. Targeting part: an anti-HER2/neu mini-antibody-barnase fusion protein (4D5 scFv-barnase-His5). The anti-HER2/neu mini-antibody could be used to deliver barnase to [...]

Automated Microfluidic Chip and System for the Synthesis of Radiopharmaceuticals on Human-Dose Scales

van Dam R.M., Elizarov A.M., Ball E., Shen C.K-F, Kolb H., Rolland J., Diener L., Williams D., Edgecombe B., Stephen T., Heath J.R., Siemens Molecular Imaging Biomarker Research, US

We present a fully-automated microfluidic system for the multi-step chemical synthesis of radiopharmaceuticals such as radiolabeled probes for positron emission tomography (PET). In earlier work, we developed a proof-of-principle PDMS microfluidic chip with a coin-shaped [...]

Coin-Shaped Reactor in Microfluidic Devices Used for Radiopharmaceutical Synthesis

Elizarov A.M., Kolb H.C., van Dam R.M., Heath J.R., Padgett H.C., Huang J., Daridon A., California Institute of Technology, US

A microfluidic device designed and optimized for the multi-step synthesis of PET (Positron Emisssion Tomography) probes is presented. It is the first device in its class to produce radiopharmaceuticals of sufficient quality and quantity (over [...]