phospholipid – TechConnect Briefs

Stability of oligodeoxynucleotide complexes with cationic phospholipid and peptide carriers

Tenchov B., Koynova R., Ahn R., O’Halloran T., MacDonald R.C., Ohio State University College of Pharmacy, US

The use of cationic lipid and peptide compounds as carriers for the intracellular delivery of oligodeoxynucleotides (ODNs) with important regulatory functions is of high current interest. Here we used X-ray diffraction, fluorescence resonance energy transfer, [...]

Lipid Dip-Pen Nanolithography for Functional Biomimetic Membrane Systems

Lenhert S., Forschungszentrum Karlsruhe GmbH, DE

Dip Pen Nanolithography (DPN) is uniquely well suited for the integration of multiple materials (or inks) with both high resolution and high throughput. Phospholipid-based inks are particularly well suited for this purpose for several reasons. [...]

Spontaneously Forming Unilamellar Nano-Sized Vesicles – Polydispersity, Size, Shape and Stability

Nieh M-P, Raghunathan V.A., Huang C-Y, Pencer J., Harroun T., Katsaras J., National Research Council at Canada, CA

Unilamellar vesicles (ULV) made up entirely of biologically relevant materials can serve as carriers for drug delivery or gene therapy. Compared to extrusion and sonication methods, traditionally used for producing ULV, spontaneously forming ULV offer [...]