pharmaceutical discovery – TechConnect Briefs

Docking and Drug Discovery

Irwin J., Lorber D.M., McGovern S.L., Wei B., Shoichet B.K., Northwestern University, US

Molecular docking screens large databases of small molecules by orienting and scoring them in the binding site of a protein. Top-ranked molecules may be tested for binding affinity in vitro, and may become lead compounds, [...]

Biotechnology and Drug Discovery: Two Years Into the Third Millennium

Bussiere D., Krause K., Chiron Corporation, US

The field of drug discovery is extremely complex and ever changing, with new methodologies and technologies being introduced constantly. The following paper provides an introduction to the field as well as the cutting-edge work being [...]